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目的探索新生儿缺血缺氧性脑病(hypoxic ischemic encephalopathy,HIE)的新的治疗方法,观察脑苷肌肽治疗中、重度新生儿缺氧缺血性脑病(HIE)疗效。方法对中、重度缺氧缺血性脑病在对症、支持及胞二磷胆碱等治疗的基础上将脑苷肌肽注射液6ml加入10%GS20～30ml中静滴,每日1次,7～10天为1个疗程。观察2组患儿在治疗前后新生儿神经行为评分(NBNA)。结果治疗组NBNA≥35分:第7、14天分别为25(48.9%)、38(84.4%)例,对照组16(25%)、33(63.9%)例,2组分别比较差异有显著性(P<0.05)。结论早期应用脑苷肌肽注射液,对HIE有治疗作用,能改善缺氧缺血性脑病患儿的神经行为能力,从而有助于其预后。治疗中未见副作用。
Objective To explore a new treatment for neonatal hypoxic ischemic encephalopathy (HIE) and to observe the therapeutic effect of cerebroside on hypoxic-ischemic encephalopathy (HIE) in moderate and severe neonates. Methods The moderate and severe hypoxic-ischemic encephalopathy in the symptomatic, support and citicoline and other treatment based on the brain glycosides carnosine injection 6ml 10% GS20 ~ 30ml intravenous infusion, once daily, 7 ~ 10 days for a course of treatment. The neonatal neurobehavioral score (NBNA) of two groups were observed before and after treatment. Results In the treatment group, the NBNA≥35 points were 25 (48.9%), 38 (84.4%) on the 7th and 14th days, 16 (25%) and 33 (63.9%) on the 7th and 14th days, respectively (P <0.05). Conclusion Early application of encephalitoside injection has a therapeutic effect on HIE, which can improve the neurobehavioral ability of children with hypoxic-ischemic encephalopathy and thus contribute to its prognosis. No side effects in treatment.