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鞘氨醇1-磷酸(Sphingosine-1-phosphate,S1P)是一种具有生物学活性的溶血磷脂信号分子,在体内通过G蛋白偶联受体(G protein coupled receptor,GPCR)家族鞘氨醇1-磷酸受体(S1P receptors)的5个亚型(S1P1-5)介导多种生物学功能。S1P4也称内皮分化基因受体6(Endothelial differentiation gene receptor 6,Edg-6),主要在淋巴组织和造血组织中表达。近年的研究发现,免疫细胞的迁移分化、骨骼肌前体细胞的迁移、乳腺癌细胞的增殖、TGFβ1介导的抑制骨骼肌细胞凋亡均与S1P4相关。本文将综述近几年来关于S1P介导S1P4的生理病理应答及相关的信号转导机制。
Sphingosine-1-phosphate (S1P) is a biologically active lysophospholipid signaling molecule that is activated in vivo by the G protein coupled receptor (GPCR) family Sphingosine 1 Five subtypes of S1P receptors (S1P1-5) mediate multiple biological functions. S1P4, also known as Endothelial differentiation gene receptor 6 (Edg-6), is mainly expressed in lymphoid tissues and hematopoietic tissues. Recent studies have found that migration and differentiation of immune cells, migration of skeletal muscle precursor cells, proliferation of breast cancer cells, TGFβ1-mediated inhibition of skeletal muscle cell apoptosis are associated with S1P4. This article reviews the recent years of S1P-mediated physiological and pathological responses to S1P4 and related signaling mechanisms.