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目前认为多发性硬化症 (ＭＳ )主要是Ｔ细胞介导的免疫紊乱导致中枢神经系统炎性脱髓鞘的自身免疫性疾病[1 ] 。Ｔ细胞活化需要第一信号和第二信号参与。第二信号由抗原递呈细胞 (ＡＰＣ )表面协同刺激分子Ｂ7分子 (配体 )和Ｔ细胞表面分子ＣＤ2 8(受体 )结合所提供 ,激活Ｔ细?
It is currently thought that multiple sclerosis (MS) is mainly an autoimmune disease of inflammatory demyelination in the central nervous system caused by T cell-mediated immune disorders [1]. T cell activation requires the participation of the first signal and the second signal. The second signal is provided by the binding of the B7 molecule (ligand) costimulatory molecule on the surface of antigen presenting cells (APC) and the CD2 8 (receptor) molecule on the T cell surface, activating the T cell?