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目的:探讨Sweet综合征的临床特点并对其组织病理学特征和治疗情况进行分析。方法:回顾性分析本院2013年至2019年期间收诊的36例Sweet综合征患者的一般资料、临床表现、实验室检查、组织病理学检查和治疗情况。结果:36例患者男女比例为1∶1，>50～60岁区间(27.8%)最好发，皮损多见于头面颈部(30.6%)、四肢(27.8%)、上肢(19.4%)及全身(22.2%)。有伴随症状者中发热(47.2%)和关节痛(19.4%)最常见。合并恶性肿瘤5例(13.9%)，合并慢性炎症或感染17例(47.2%)，合并糖尿病4例(11.1%)，合并妊娠3例(8.3%)。临床最常误诊为多形红斑(11.1%)和过敏性皮炎(11.1%)。组织病理均表现为真皮乳头水肿，真皮中性粒细胞浸润及核尘。所有患者经糖皮质激素治疗后均明显好转。结论:Sweet综合征男女发病比例接近相同，慢性感染和恶性肿瘤是最常见的发病诱因，临床容易误诊，全面评估患者系统性疾病以及准确的组织病理学分析有助于早期识别并诊断Sweet综合征。“,”Objective:To explore the clinical features of Sweet′s syndrome and analyze its histopathological features and treatment.Methods:The general data, clinical manifestations, laboratory examination, histopathological examination and treatment of 36 patients with Sweet′s syndrome who admitted our hospital from 2013 to 2019 were retrospectively analyzed.Results:The male to female ratio is 1∶1, with the highest incidence in the 50-60 years old range (27.8%). Skin lesions were more common in head and neck (30.6%), limbs (27.8%), upper limbs (19.4%) and whole body (22.2%). Accompanying symptoms were observed in 20 patients (55.6%) and most common are fever (47.2%) and joint pain (19.4%). Malignant tumors were associated with 5 patients (13.9%), chronic inflammation or infection with 17 patients (47.2%), diabetes mellitus with 4 patients (11.1%) and pregnancy with 3 patients (8.3%). It is most easily misdiagnosed as erythema polyforms (11.1%) and allergic dermatitis dermatitis (11.1%). Histopathologic features ware dermal papillary edema, dermal neutrophilic infiltration and nuclear dust. All patients relieved after glucocorticoid therapy.Conclusions:The proportion of male and female in Sweet syndrome is close to the same. Chronic infection and malignant tumor are the most common causes, which are easy to be misdiagnosed in clinic. Comprehensive evaluation of patients′ systemic diseases and accurate histopathological analysis are helpful for early identification and diagnosis of Sweet syndrome.