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带有hCG作为膜标记的肿瘤细胞,如绒毛膜癌细胞,其免疫学检测和治疗是有可能的,但需要高特异性的试剂、标准化的生物特性。如亲和力、补体结合力、K细胞活化以及不具有增强作用。单克隆抗体(MCA)能满足所有这些需要,因此能用于这些疾病的免疫学干扰。 为此,将免疫了hCG的小鼠脾细胞与小鼠骨髓瘤细胞融合在一起,形成杂交瘤细胞系。通过对标记了~(125)I的hCG、人黄体激素(hLH)、人卵泡
Tumor cells with hCG as a membrane marker, such as choriocarcinoma, are immunologically detectable and therapeutically available, but require highly specific reagents and standardized biological properties. Such as affinity, complement fixation, K-cell activation, and no enhancement. Monoclonal antibodies (MCA) meet all of these needs and can therefore be used for immunological interference with these diseases. To this end, mouse immunized hCG splenocytes were fused with mouse myeloma cells to form a hybridoma cell line. Through the labeling of ~ (125) I hCG, human luteinizing hormone (hLH), human follicles