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目的探讨胃癌组织中人表皮生长因子受体(EGFR)、表皮生长因子受体-2(HER-2)和环氧合酶-2(COX-2)的表达及与临床病理特征的关系。方法应用免疫组织化学Envision二步法,检测70例胃癌组织中EGFR、HER-2和COX-2的表达情况,并结合其临床病理特点进行分析。结果 EGFR、HER-2和COX-2在胃癌组织中的表达阳性率分别为35.7%(25/70)、27.1%(19/70)、67.1%(47/70)。阳性表达与肿瘤分化程度、侵袭深度、有无淋巴结转移及TNM分期有关(P<0.05),而与患者的性别及年龄、肿瘤部位和大小无关(P>0.05)。EGFR、HER-2和COX-2三者之间在胃癌组织中的表达均呈正相关(P<0.05)。结论 EGFR、HER-2和COX-2的表达参与胃癌的生长、侵袭和转移过程。它们的联合检测有助于胃癌患者靶向药物的选择,也为胃癌的预后判断提供客观的参考指标。
Objective To investigate the expression of human epidermal growth factor receptor (EGFR), epidermal growth factor receptor-2 (HER-2) and cyclooxygenase-2 (COX-2) in gastric cancer and their clinicopathological characteristics. Methods The expressions of EGFR, HER-2 and COX-2 in 70 cases of gastric cancer were detected by immunohistochemistry Envision two-step method and analyzed with clinicopathological features. Results The positive rates of EGFR, HER-2 and COX-2 in gastric cancer tissues were 35.7% (25/70), 27.1% (19/70) and 67.1% (47/70), respectively. The positive expression was related to the degree of tumor differentiation, depth of invasion, lymph node metastasis and TNM stage (P <0.05), but not related to sex, age, tumor location and size (P> 0.05). The expressions of EGFR, HER-2 and COX-2 in gastric cancer tissues were positively correlated (P <0.05). Conclusion The expressions of EGFR, HER-2 and COX-2 are involved in the growth, invasion and metastasis of gastric cancer. Their combined detection can be helpful for the selection of targeted drugs in patients with gastric cancer and also provides an objective reference for the prognosis of gastric cancer.