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目的探讨湖北钟祥河南移民与湖北本地居民食管鳞状细胞癌组织中人乳头状瘤病毒(humanpapillomavirus,HPV)感染的情况。方法应用免疫组化SP方法,检测82例食管癌组织中PV和HPV感染情况。以正常食管手术残端黏膜组织作正常对照。结果钟祥食管癌高发区、麻城地区、湖北省肿瘤医院标本中PV阳性感染率分别为75%、68.18%、72.5%。HPV分别为45%、36.36%、37.5%。PV、HPV的阳性表达与食管鳞癌具有显著相关(P<0.05),正常食管黏膜组织中PV、HPV均为阴性。结果未发现PV、HPV阳性细胞与食管癌细胞分化程度有明显相关性(P>0.05)。在三组研究对象之间PV、HPV的阳性率未显示统计学差异(P>0.05)。结论湖北钟祥河南移民及湖北其他地区居民食管癌组织中可能存在HPV感染。HPV在一定的地域环境中与食管癌发生、发展的关系可能具有普遍意义。
Objective To investigate the infection of human papillomavirus (HPV) in esophageal squamous cell carcinoma of Henan Province, Zhongxiang, Hubei and Hubei natives. Methods Immunohistochemical SP method was used to detect PV and HPV infection in 82 cases of esophageal cancer. Normal esophageal stump mucosa tissue as a normal control. Results Zhongxiang esophageal cancer high incidence area, Macheng area, Hubei Provincial Tumor Hospital specimens PV positive infection rates were 75%, 68.18%, 72.5%. HPV were 45%, 36.36%, 37.5% respectively. The positive expression of PV and HPV was significantly correlated with esophageal squamous cell carcinoma (P <0.05), and both PV and HPV in normal esophageal mucosa were negative. The results did not find PV, HPV-positive cells and esophageal cancer cell differentiation was significantly correlated (P> 0.05). There was no statistical difference in the positive rate of HPV between the three groups of subjects (P> 0.05). Conclusion There may be HPV infection in immigrants from Zhongxiang, Hubei Province and esophageal cancer in other areas of Hubei Province. HPV in a certain geographical environment and the occurrence and development of esophageal cancer may have universal significance.