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卤代碳负离子易发生α-消除反应,消除卤离子产生相应的卡宾中间体。当碳负离子上同时连接有其它离去基团时,则可能有几种结果,或专一性地产生一种卡宾,或同时产生两至三种卡宾:本文报道二氯甲基膦酸二乙酯负离子(1)α-消除反应的结果。1可由单氯或三氯甲基膦酸二乙酯经Li-Cl交换反应产生,也可由二氯甲基膦酸二乙酯直接产生。有关1与各种亲电试剂的反应已有不少报道,但1的α-消除反应尚未见诸文献。1的α-消除反应可能产生两种卡宾中间体:
Halocarbon anion prone to α-elimination reaction, eliminating the halide ion to produce the corresponding carbene intermediates. When other leaving groups are attached to the carbanion at the same time, then several results may be obtained, either specifically to produce one carbene or two to three carbenes simultaneously: Ester negative ion (1) α-elimination reaction results. 1 can be produced from monochloride or diethyl trichloromethylphosphonate via Li-Cl exchange reaction, or directly from diethyl dichloromethylphosphonate. There have been many reports on the reaction of 1 with various electrophiles, but the α-elimination reaction of 1 has not been reported yet. 1 α-elimination reaction may produce two carbene intermediates: