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目的对比观察奥施康定(盐酸羟考嗣控释片)和芬太尼透皮贴治疗慢性中、重度癌痛的疗效和不良反应。方法 84例中、重度癌痛患者随机分为奥施康定治疗组或芬太尼透皮贴组。奥施康定组初始剂量10mg/12h,正在用吗啡镇痛者,按照吗啡0.5剂量换算。芬太尼透皮贴组初始剂量为25μg/h,正在用吗啡镇痛者,按照芬太尼透皮贴(μg/h)=每日吗啡剂量(mg)×0.5换算。根据疼痛情况调整剂量,每位患者至少治疗两周,同时进行疼痛强度、生活质量评分及不良反应观察。结果奥施康定组41例疼痛缓解率为92.68%;多瑞吉组43例为93.02%。两组患者生活质量均明显提高,主要不良反应为便秘。结论奥施康定和多瑞吉治疗中、重度癌痛疗效均显著,不良反应较少,能显著改善癌症患者的生活质量。
Objective To observe the curative effect and adverse reactions of oxycodone hydrochloride and fentanyl transdermal patch in the treatment of chronic moderate and severe cancer pain. Methods 84 patients with severe cancer pain were randomly divided into OxyContin treatment group or transdermal fentanyl group. Oxycycline group initial dose of 10mg / 12h, morphine analgesia are being used, according to the morphine 0.5 dose conversion. The initial dose of the fentanyl transdermal patch group was 25 μg / h and conversion to morphine analgesia was based on fentanyl transdermal patch (μg / h) = daily dose of morphine (mg) × 0.5. According to the pain adjustment dose, each patient for at least two weeks, while pain intensity, quality of life scores and adverse reactions observed. Results The pain relief rate in 41 cases of Oxycodin group was 92.68%, and 43.02% in Duogui Ji group. Both groups of patients were significantly improved quality of life, the main adverse reactions for constipation. Conclusion Oxycodin and Doric treatment are effective in treating moderate and severe cancer pain with less adverse reactions and can significantly improve the quality of life of cancer patients.