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缺血预适应作为心脏内源性的保护机理之一涉及细胞内多种复杂的变化。其中细胞Ca2 + 在缺血预处理期间短暂轻度升高或以启动细胞内第二信使系统 ,改变细胞内各种Ca2 + 的转运 ,减轻缺血再灌注期细胞内Ca2 + 的升高 ,产生对心脏的保护作用。在缺血预适应期及缺血再灌注期 ,细胞内Ca2 + 的变化涉及细胞膜L Ca2 + 型通道、细胞内肌浆网、线粒体及细胞膜Na+ /Ca2 + 交换等方面的变化
Ischemic preconditioning, as one of the endogenous protective mechanisms of the heart, involves many complex changes in the cell. Among them, the cell Ca2 + transiently mildly elevated during ischemic preconditioning or to start the second intracellular messenger system, changing intracellular Ca2 + transport, reduce intracellular Ca2 + during ischemia reperfusion period, resulting in The protection of the heart. During ischemic preconditioning and ischemia / reperfusion, changes in intracellular Ca2 + are involved in the changes of L Ca2 + channel, intracellular sarcoplasmic reticulum, mitochondria and Na + / Ca2 + exchange in the plasma membrane