论文部分内容阅读
采用多导描记技术分别观察了硝基左旋精氨酸（Ｌ－ＮＮＡ）和左旋精氨酸（Ｌ－Ａｒｇ）腹腔注射（剂量分别为５０ｍｇ／ｋｇ，１１０ｍｇ／ｋｇ）对大鼠睡眠及动脉血压的影响。结果：Ｌ－ＮＮＡ显著抑制慢波睡眠和快眼动睡眠，使动脉血压升高。Ｌ－Ａｒｇ对睡眠及血压无明显影响。预先给予Ｌ－Ａｒｇ，再给予Ｌ－ＮＮＡ可逆转Ｌ－ＮＮＡ所致的睡眠缺失和血压变化。提示：内源性－氧化氮参与睡－醒周期的调节，Ｌ－ＮＮＡ对睡眠的影响并非血压升高所致。
The effects of L-arginine (L-NNA) and L-arginine (L-Arg) on the sleep and arterial pressure of rats were observed by intraperitoneal injection of 50 mg / kg and 110 mg / Impact. Results: L-NNA significantly inhibited slow wave sleep and rapid eye movement sleep, arterial blood pressure. L-Arg had no significant effect on sleep and blood pressure. Pre-administration of L-Arg followed by L-NNA reverses L-NNA-induced sleep loss and changes in blood pressure. Tip: endogenous - nitric oxide involved in sleep - wake cycle regulation, L-NNA on sleep is not due to elevated blood pressure.