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目的 :分析近年梅毒发病的临床特征及不同药物对愈后的影响。方法 :对近 5年门诊资料完整的 98例早期梅毒病例进行临床及实验室追踪随访调查。结果 :①一期梅毒 2 1例 ,二期梅毒 72例 ,早期潜伏梅毒 5例。血清RPR及FTA ABS全部阳性。治疗 1年血清转阴率 :RPR及FTA ABS分别为 10 0 %,2 0 4 1%;②临床特点 :1例 73岁男性高龄发病 ,2例多种皮损共存 ,3例阴囊湿疹样皮损 ,门诊误诊率 7 14%;③ 3组药物 (A 苄星青霉素 ;B 头孢三嗪 ;C 红霉素 )治疗 :AB组P >0 0 5 ;BC组P <0 0 5 ;CA组P <0 0 5 ;结论 :近年早期梅毒发病年龄增大 ,皮损的多样性使误诊率增高 ;目前苄星青霉素仍不失为治疗早期梅毒的首选药 ,头孢三嗪亦有较好疗效 ;RPR检测仍是临床判愈的重要指标。
Objective: To analyze the clinical characteristics of syphilis in recent years and the influence of different drugs on the prognosis. Methods: A total of 98 early syphilis cases with complete outpatient data in the past five years were investigated by clinical and laboratory follow-up. Results: There were 21 cases of primary syphilis, 72 cases of secondary syphilis and 5 cases of early latent syphilis. Serum RPR and FTA ABS all positive. Serum conversion rate of 1 year of treatment: RPR and FTA ABS were 10 0%, 2 0 4 1%; 2 clinical features: a 73-year-old man with age-related disease, 2 cases of multiple skin lesions coexist, 3 cases of scrotal eczematous skin The misdiagnosis rate of outpatient was 7 14%; ③ The treatment of 3 groups of drugs (A benzathine penicillin; B ceftriaxone; C erythromycin): AB group P> 0 05; BC group P 0 05; CA group P <0 0 5; Conclusions: The incidence of syphilis increased in early years and the misdiagnosis rate increased. Currently, benzathine penicillin is still the first choice for the treatment of early syphilis and ceftriaxone is also effective. RPR Clinical judgment is an important indicator.