细胞增殖与凋亡是肿瘤发生发展的主要因素。凋亡抑制蛋白(IAPs)因其抑制细胞凋亡而与肿瘤的发生发展关系密切,对肿瘤的预测、诊断、治疗及预后有重要价值,近年成为医学界的研究热点之一。现将IAPs的分子结构、生物学功能及其在妇科恶性肿瘤中的研究进展作一综述。 Cell proliferation and apoptosis are the main factors of tumor development. Apoptosis inhibitory proteins (IAPs) are closely related to tumorigenesis and development because of their inhibitory effect on apoptosis. They are of great value in the prediction, diagnosis, treatment and prognosis of tumors. In recent years, they have become one of the hot topics in the field of medicine. Now IAPs molecular structure, biological function and its progress in gynecologic malignancies are reviewed.