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目的:观察复方顽痛宁酊对小鼠疼痛模型的影响及其临床疗效。方法:先进行药理实验,实验选用小鼠扭体法和小鼠热板法分别观察复方顽痛宁酊的镇痛效果并与麝香祛痛搽剂进行比较,再进行临床观察。结果:实验结果表明:小鼠扭体法实验,空白对照组为22.5±3.7次,复方顽痛宁酊组小鼠扭体次数为4.2±1.8次,阳性对照组麝香祛痛搽剂为14.2±2.8次,复方顽痛宁酊组减少小鼠扭体次数与空白对照组和阳性对照相比较有显著差异。小鼠热板法:复方顽痛宁酊组延长小鼠舔后足时间与空白对照组和阳性对照比较有显著差异。临床观察结果表明,复方顽痛宁酊对癌性疼痛有显著的疗效。结论:通过实验证明复方顽痛宁酊具有良好的镇痛作用,且起效快、持续时间长。临床观察也表明复方顽痛宁酊有明显的镇痛效果。
Objective: To observe the effect of compound Tongtongning tincture on the pain model of mice and its clinical effect. Methods: The first pharmacological experiments, experiments using mouse writhing method and the mouse hot plate method were observed Compound Nongtongning tincture of analgesic effect and musk Qushi Tong liniment, and then the clinical observation. Results: The experimental results showed that the writhing test in mice was 22.5 ± 3.7 times in the blank control group, the number of writhing was 4.2 ± 1.8 times in the compound Tongtongning tincture group, and that in the positive control group was 14.2 ± 2.8 times, compound Tongtongning tincture reduce the number of writhing in mice compared with the blank control group and positive control were significantly different. Mouse hot-plate method: Compound Tongtongning tincture group to prolong the licking time after mice licking compared with the blank control group and positive control were significantly different. Clinical observations show that compound Tongtongning tincture of cancer pain have a significant effect. Conclusion: The experiment shows that Compound Nongtongning Tincture has good analgesic effect, fast onset and long duration. Clinical observation also showed that compound Tongtongning tincture has obvious analgesic effect.