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将3-丙烯酰胺基苯硼酸与马来酸酐改性β-环糊精反应,合成了一种新型的共聚物,并采用13C NMR,IR和UV-Vis等技术对共聚物的结构进行了表征.利用SEM研究了聚合物在甲醇中的自组装形态.通过在不同溶剂中溶解性能的研究,探讨了共聚物与甲醇的络合机理以及自组装机理.以格列奇特为模型药物,研究了聚合物微球在不同环境下的振荡释放行为.结果表明,载药微球在30 min内对葡萄糖刺激迅速响应,在葡萄糖浓度为3 g/L和无糖环境之间的振荡释放呈“开-关”式自调释放.
A novel copolymer was synthesized by the reaction of 3-acrylamidobenzene boronic acid with maleic anhydride-modified β-cyclodextrin. The structure of the copolymer was characterized by 13C NMR, IR and UV-Vis The self-assembly morphology of the polymer in methanol was studied by means of SEM.The complexation mechanism of the copolymer with methanol and the self-assembly mechanism were discussed by studying the solubility in different solvents.With Gliclazide as a model drug, The results showed that the drug-loaded microspheres responded promptly to glucose stimulation within 30 min, and the oscillation release between the glucose concentration of 3 g / L and the sugar-free environment was “ On-off ”self-regulation release.