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并用人乳头瘤病毒杂交捕获法(hc2HPVDNA)和液基细胞检测法(TCT)联合监测宫颈癌前病变,提高诊断率。用hc2HPVDNA和TCT两种方法检测1231例宫颈外口及颈管脱落细胞和分泌物。1231例样本中,HPV感染率34.0%,而21～40岁年龄段略高于其它年龄段。TCT检测:正常+炎症1077例;ASCus32例;ASCh34例;LSIL73例,HSIL15例。ASCus、ASCh、LSIL和HSIL检出率分别为2.6%、2.8%、5.9%和1.2%。在细胞学诊断为ASCus、ASCh、LSIL和HSIL组中,HPV感染率分别为50.0%、58.8%、76.7%和93.3%。统计学检验表明:细胞形态和结构的异常与HPV感染具有高度相关性(p<0.01)。TCT检查证实细胞形态正常者中,HPV感染率占29.0%;当细胞形态和结构出现异常时,HPV的感染率明显增加(HSIL>LSIL>ASCh>ASCus>正常+炎症)。
Human papillomavirus hybridization capture method (hc2HPVDNA) and liquid-based cell detection (TCT) were combined to monitor precancerous lesions of the cervix and improve the diagnostic rate. Using hc2HPVDNA and TCT two methods to detect 1231 cases of cervical exocrine and cervical exfoliative cells and secretions. Among 1231 samples, the HPV infection rate was 34.0%, while the 21-40 age group was slightly higher than the other age groups. TCT test: normal + inflammation in 1077 cases; ASCus32 cases; ASCh34 cases; LSIL73 cases, HSIL15 cases. ASCus, ASCh, LSIL and HSIL detection rates were 2.6%, 2.8%, 5.9% and 1.2% respectively. In the cytological diagnosis of ASCus, ASCh, LSIL and HSIL group, the HPV infection rates were 50.0%, 58.8%, 76.7% and 93.3%. Statistical tests showed that cell morphology and structural abnormalities were highly correlated with HPV infection (p <0.01). HPV infection rate was 29.0% in patients with normal cell morphology by TCT examination. HPV infection rate was significantly increased when cell morphology and structure were abnormal (HSIL> ASC> ASCus> normal + inflammation).