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目的探讨重型颅脑损伤患者脑氧摄取量(CEO2)及脑葡萄糖摄取量(CEG)的变化规律及对预后的影响。方法选择同期存活超过7天的重型颅脑损伤患者62例,在入院或手术后12h内、第3天、第7天分别同步在颈内静脉球部及股动脉抽取血样进行血气分析及血糖检查,计算出CEO2及CEG,对存活病人及死亡病人进行对比分析。结果存活47例,死亡15例。在伤后12h内存活组及死亡组的CEO2、CEG差异无显著性(P均>0.05),第3天起出现进行性下降;第7天死亡组病人的CEO2和CEG均显著低于存活组(P均<0.01)。结论对重型颅脑损伤患者实施动态监测CEO2及CEG,对正确掌握病情、估计预后和指导抢救治疗具有重要意义。
Objective To investigate the changes of cerebral oxygen intake (CEO2) and cerebral glucose uptake (CEG) in patients with severe craniocerebral injury and its prognostic significance. Methods Sixty-two patients with severe craniocerebral injury who survived more than 7 days during the same period were enrolled. Blood samples were taken from the internal jugular bulb and femoral artery simultaneously on the 3rd and 7th day after admission or intraoperatively for blood gas analysis and blood glucose test , Calculated CEO2 and CEG, the survival of patients and death patients for comparative analysis. Results Survival in 47 cases, 15 cases of death. There were no significant differences in CEO2 and CEG between the surviving group and the dead group within 12 hours after injury (P> 0.05), and there was a progressive decrease on the 3rd day. On the 7th day, CEO2 and CEG in the death group were significantly lower than those in the surviving group (P <0.01). Conclusions The dynamic monitoring of CEO2 and CEG in patients with severe craniocerebral injury is of great importance in correctly grasping the disease, estimating the prognosis and guiding the rescue and treatment.