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Thymus is the primary lymphoid organ involved in the development of thymocytes.Maturation related eventsof thymocytes within thymus,especially the widely discussed directional migration of thymocytes,is regulatedby chemokines via chemokine receptors mediated signaling pathway.Multiple types of chemokines andchemokine receptors,as components of the network-interaction within thymic microenvironment,are involvedin the thymopoiesis.It appears that these chemokines are functionally redundant and such phenomenon maybe explained not only by the promiscuous,non-one-to-one matching between ligands-receptors within CXC orCC chemokine subfamily,but also by the various spatio-temporal expression patterns within different celltypes and developmental stages.The redundancy and regulation of thymus expressed chemokines andchemokine receptors during thymocyte development are herein discussed.Cellular & Molecular Immunology.2004;1(4):266-273.
Thymus is the primary lymphoid organ involved in the development of thymocytes. Especially engaged in the migration of thymocytes, especially regulated diversion of thymocytes by thymocytes, especially regulated by chemokines via as chemokine receptors mediated signaling pathway. Multiple components of chemokines and chemokine receptors, as components of the network-interaction within thymic microenvironment, are involved in the thymopoiesis. It appears that these chemokines are functionally redundant and such phenomena maybe not only by the promiscuous, non-one-to-one matching between ligands-receptors within CXC or CC chemokine subfamily, but also by the various spatio-temporal expression patterns within different celltypes and developmental stages. The redundancy and regulation of thymus expressed chemokines and chemokine receptors during thymocyte development are discussed. Cellular & Molecular Immunology. 2004; 1 (4): 266-273.