OBJECTIVE To investigate the potency of Urena lobata leaves extract on the inhibition of hepatic complication on diabetic rats.METHODS This study uses control group post test only with male Sprague dawley rats.Diabetic rats was induced by high fructose diet(HFD)and single dose streptozotocin 25mg·kg-1 bw intra peritoneal.The rat was administrated orally with water extract of U.lobataleaves in concentrations of 250,500 and 1000mg·kg-1 bw for 4 weeks.After scarifying,liver organ and blood were collected and then superoxyde dismutase(SOD)hepar level,malondialdehyda(MDA),tumor necrosis factor-alpha(TNF-α),serum glutamic oxaloacetic transaminase(SGOT)and serum glutamic piruvic transaminase(SGPT)were examined.The data was analyzed using ANOVA test continued with LSD test(P<0,05).RESULTS The oral administration of U.lobataleaves extract 250,500 and 1000mg·kg-1 bw were able to increase SOD hepar level about 90%,100% and 120%respectively compared to diabetic group(P<0.05),while the MDA hepar level was decreased by 40%,50% and 70% respectively(P<0.05),whereas the TNF-αhepar level was decreased by 30%,50% and 70%respectively(P<0.05).The supplementation of water extract from U.lobatain dose of 250,500 and 1000mg·kg-1 bw decrease SGOT level approximately10%,30% and 50% compared to control group(P<0.05),while the SGPT level was decreased by 10%,20% and 40%respectively(P<0.05).In diabetic groups,SOD heparlevel was decreased compared to normal group(P<0.05)whereas the MDA and TNF-αwere increased(P<0.05).Meanwhile SGOT level and SGPT were increased in diabetic group(P<0.05).CONCLUSION U.lobataleaves extract could inhibit hepatic complication on diabetic rats by increasing of SOD hepar level,decreasing of MDA hepar level,TNF-α,SGOT and SGPT.This effect may be related to active compounds that act as an antioxidant and anti-inflammatory in U.lobata extract. OBJECTIVE To investigate the potency of Urena lobata leaves extract on the inhibition of hepatic complication on diabetic rats. METHODS This study uses control group post test only with male Sprague Dawley rats. Diabetic rats was induced by high fructose diet (HFD) and single dose streptozotocin 25 mg · kg -1 bw intra peritoneal. The rat was administered orally with water extract of U.lobataleaves in concentrations of 250,500 and 1000 mg · kg -1 bw for 4 weeks. After scarifying, liver organ and blood were collected and then superoxyde dismutase ( SOD) hepar level, malondialdehyda (MDA), tumor necrosis factor-alpha (TNF-α), serum glutamic acid oxaloacetic transaminase (SGOT) and serum glutamic piruvic transaminase (SGPT) were measured.The data was analyzed using ANOVA test continued with LSD test (P <0,05) .RESULTS The oral administration of U.lobataleaves extract 250,500 and 1000 mg · kg -1 bw were able to increase SOD hepar level about 90%, 100% and 120% respectively compared to diabetic group (P <0.05 ), while the MDA hepa The level of decreased TNF-α was decreased by 30%, 50% and 70% respectively (P <0.05). The supplementation of water extract from While the SGPT level was decreased by 10%, 20% and 40% respectively compared to the control group (P <0.05), U.lobatain dose of 250,500 and 1000 mg · kg -1 bw decrease SGOT level approximately10%, 30% and 50% compared to control group (P <0.05) .In diabetic groups, SOD heparlevel was decreased compared to normal group (P <0.05), while MDA and TNF-αwere increased 0.05) .CONCLUSION U.lobataleaves extract could inhibit hepatic complication on diabetic rats by increasing of SOD hepar level, decreasing of MDA hepar level, TNF-α, SGOT and SGPT. This effect may be related to active compounds that act as an antioxidant and anti-inflammatory in U.lobata extract.