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用MTT法检测补骨脂素、γ干扰素及两者联合应用对人舌癌细胞系HSC3的生长抑制作用,它们的半抑制浓度(LC50)分别为25119ng/ml和371535u/ml。当γ干扰素浓度为100u/ml时与补骨脂素合用呈相加效应;浓度为1000~100000u/ml时合用呈协同效应,。补骨脂素、γ干扰素及两者联合应用对HSC3细胞裸鼠移植瘤的抑瘤率分别为83.1%、67;6%和102.9%,两药合用呈协同效应;受试鼠体重减轻率分别为5%、1.2%和1.8%,对照组体重减轻12.5%。结果提示联合用药具有明显的协同效应,而且有助于改善机体的全身情况。
The inhibitory effect of psoralen and interferon-γ on the growth of human tongue cancer cell line HSC3 was detected by MTT assay. Their half-inhibitory concentrations (LC50) were 25,119 ng / ml and 37,1535 u / ml, respectively. When γ interferon concentration of 100u / ml and psoralen combined effect was showed; when the concentration of 1000 ~ 100000u / ml synergistic effect when combined. The inhibitory rates of psoralen, interferon-γ and their combination on the xenografts of HSC3 nude mice were 83.1%, 67.6% and 102.9%, respectively. The combination of the two drugs showed a synergistic effect. Rat weight loss rates were 5%, 1.2% and 1.8%, respectively, in the control group 12.5% weight loss. The results suggest that combination therapy has obvious synergistic effect, and helps to improve the body's general condition.