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为观察补气通络方对周围神经损伤的治疗效果 ,给临床用药提供依据。采用清洁级 Wistar大鼠 48只 ,行右坐骨神经横形切断后即刻原位吻合术 ,制成周围神经损伤模型后 ,随机分为补气通络胶囊组、补气通络注射剂组、维生素 B1 、B6 组和空白对照组。分别在给药后 4、8、12周以坐骨神经功能指数 (SFI)、坐骨神经传导速度 (NCV)和小腿三头肌湿重 (WWT)测定为观测指标 ,判断神经功能的修复情况。结果显示补气通络方两个治疗组的坐骨神经功能指数、神经传导速度及小腿三头肌湿重均比维生素B1 + B6 组和空白组恢复快 (P<0 .0 5或 P<0 .0 1)。表明补气通络方对周围神经损伤后神经功能的恢复有促进作用
To observe the therapeutic effect of Buqi Tongluo on peripheral nerve injury, and provide basis for clinical drug use. 48 Wistar rats of clean grade were used to perform immediate in situ anastomosis after the right sciatic nerve was cut transversely. After being made into a peripheral nerve injury model, they were randomly divided into Buqi Tongluo Capsule Group, Buqi Tongluo Injection Group, Vitamin B1, and B6. Group and blank control group. The sciatic nerve function index (SFI), sciatic nerve conduction velocity (NCV), and triceps femoral wet weight (WWT) were measured at 4, 8, and 12 weeks after administration to determine the repair of neurological function. The results showed that the sciatic nerve function index, nerve conduction velocity, and wet weight of triceps brachii in the two treatment groups of Buqi Tongluo group were faster than that of vitamin B1 + B6 group and blank group (P<0.05 or P<0. 0 1). Shows that Buqi Tongluo Fang can promote the recovery of nerve function after peripheral nerve injury