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Based on the active site of Aspergillus fumigatus lanosterol 14a-demethylase(AF-CYP51),novel triazole compounds weredesigned.Their chemical synthesis and the antifungal activities were reported.The results showed that all the target compoundsexhibited excellent activities with broad spectrum;in which compounds 4,12 and 15 showed comparable activities against A.fumigatus to the control drug itraconazole.
Based on the active site of Aspergillus fumigatus lanosterol 14a-demethylase (AF-CYP51), novel triazole compounds were desirably.Their chemical synthesis and the antifungal activities were reported. The results showed that all the target compound sexhibited excellent activities with broad spectrum; in which compounds 4,12 and 15 showed comparable activities against A. fumigatus to the control drug itraconazole.