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目的：观察及评估硫糖铝联用黄连素对慢性顽固性胃炎的治疗效果。方法选取我院收治的70例慢性顽固性胃炎患者作为观察对象，收治时间为2013年6月~2014年12月，采用随机分组的方式将其分成两组，每组35例。对照组采取硫糖铝进行治疗，实验组在对照组的基础上采取黄连素进行治疗，观察比较两组慢性顽固性胃炎患者的临床疗效、幽门螺旋杆菌转阴率以及复发率。结果对照组的总有效率（77.14%）显著低于实验组的总有效率（94.29%）；两组慢性顽固性胃炎患者的幽门螺旋杆菌转阴率以及复发率的比较结果存在显著差异，<0.05，差异有统计学意义。结论对慢性顽固性胃炎患者采取硫糖铝联用黄连素进行治疗，能够有效改善患者的临床症状，提高幽门螺旋杆菌转阴率，效果显著，且患者复发率较低。“,”Objective To observe the therapeutic effect and evaluation of sucralfate combined with berberine.Methods 70cases of chronic gastritis patients treated in our hospital as the observation object,treated time for December2014to June 2013,the use of random grouping of the two groups, each group of 35 cases.The control group took sucralfate treatment,the experimental group in the control group on the basis of taking berberine treatment,observe the clinical efficacy of the two groups,chronic gastritis with Helicobacter pylori negative rate and recurrence rate.Results The total efficiency of the control group (77.14%)was significantly lower than the experimental group the total efficiency (94.29%);there were significant differences between the two groups of chronic gastritis patients with Helicobacter pylori negative rate and recurrence rate of the results of the comparison, <0.05,the difference was statistically significant.Conclusion Sucralfate combined with berberine for the treatment of patients with chronic gastritis,can effectively improve the clinical symptoms of the patients,improve the Helicobacter pylori negative rate,the effect is significant,and the recurrence rate is low.