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目的：观察芪灵胶囊对自然杀伤细胞（ＮＫ）活性的影响。方法：采用３Ｈ－ＴｄＲ标记靶细胞释放法，以杀伤率和抑制率为测定指标；采用细胞病变抑制法，以血清干扰素（ＩＦＮ）效价为测定指标。结果：芪灵胶囊体外可不同程度地增加正常和环磷酰胺（ＣＹ）抑制的小鼠脾ＮＫ活性；对ＣＹ抑制模型鼠体内给药后可明显提高ＮＫ杀伤活性（Ｐ＜０．０１）及血清ＩＦＮ水平（Ｐ＜０．０１），对正常鼠无明显作用（Ｐ＞０．０５）。结论：芪灵胶囊可在一定程度上保护ＮＫ抵抗ＣＹ的抑制作用，其作用可能是通过提高血清ＩＦＮ水平来实现的
Objective: To observe the effect of Qi Ling Capsule on natural killer cell (NK) activity. Methods: 3H-TdR labeled target cell release method was used to determine the killing rate and inhibition rate. The cytopathic inhibition method was used to determine the serum IFN titers. RESULTS: Buling capsules can increase the activity of spleen NK in mice with normal and cyclophosphamide (CY) inhibition in vitro, and can significantly increase NK killing activity in CY-inhibitory model mice (P<0.01). Serum IFN levels (P<0.01) had no significant effect on normal rats (P>0.05). Conclusion: Qi Ling capsule can protect the inhibition effect of NK against CY to a certain extent, and its effect may be achieved by increasing serum IFN level.