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目的设计周围血管扩张药环扁桃酯的新合成路线。方法以苯为原料,与草酰氯单乙酯反应制备苯乙酮酸乙酯(2),2与顺式3,3,5-三甲基环己醇通过酯交换合成顺式3,3,5-三甲基环己醇苯乙酮酸酯(3),3在锌粉和甲酸铵条件下发生还原得到环扁桃酯。结果与结论合成目标化合物的总收率为59.6%,目标化合物的结构经1H-NMR、13C-NMR、IR谱确证。新合成路线具有原料廉价易得、操作简便、收率高的特点。
Objective To design a new synthetic route of peripheral vasodilator almonds. Methods Benzene ethyl oxalate (2) was synthesized by the reaction of benzene with oxalyl chloride monoethyl ester. The cis - 3, 3, 5-trimethylcyclohexanol acetophenate (3), 3 reduction occurs under the conditions of zinc powder and ammonium formate to give cyclic almond ester. Results and Conclusion The total yield of the target compound was 59.6%. The structure of the target compound was confirmed by 1H-NMR, 13C-NMR and IR. The new synthetic route with cheap raw materials, easy to operate, high yield characteristics.