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目的：通过对４２ 例先兆早产和３０ 例正常无症状孕妇进行宫颈阴道分泌物催乳素（ＰＲＬ） 、卵巢癌抗原（ＣＡ１２５） 的检测，预测早产，降低早产儿的发病率和病死率。方法：采用放射免疫测定法。结果：两组间宫颈阴道分泌物中ＰＲＬ阳性率具有显著性差异，而ＣＡ１２５ 阳性率在两组间无差异性。ＰＲＬ阳性组妊娠结局较阴性者为差，ＰＲＬ阳性预测早产的敏感性、特异性均较高，分别达７６．６７％ 和９０．４８％ ，ＣＡ１２５ 阳性预测早产其敏感性仅为２０．００ ％ 。结论：ＰＲＬ在孕妇宫颈阴道分泌物中的浓度可作为预测早产的指标，ＣＡ１２５ 无明显意义。
OBJECTIVE: To detect preterm labor and reduce morbidity and mortality in preterm infants by detecting the vaginal secretion of prolactin (PRL) and ovarian cancer antigen (CA125) in 42 cases of threatened preterm birth and 30 cases of normal asymptomatic pregnant women. Methods: Radioimmunoassay was used. Results: The positive rates of PRL in cervicovaginal secretions between the two groups were significantly different, while the positive rates of CA125 were not different between the two groups. PRL positive group had worse pregnancy outcomes than those with negative ones. The sensitivity and specificity of PRL positive predictive rate of preterm birth were high, reaching 76.67% and 90.48% respectively. The sensitivity of CA125 positive predicting premature delivery was only 20.00% . Conclusion: The concentration of PRL in cervical vaginal secretions of pregnant women can be used as an index to predict preterm birth, and CA125 has no obvious significance.