1963年,Laurell及Eriksson首先发现了血清α_1—抗胰蛋白酶(α_1-Antitrypsin,α1-AT)缺乏与中年期肺气肿有密切关系。1968年,Eriksson提出了蛋白酶—抗蛋白酶平衡假说,认为肺气肿的形成是一种进行性的肺泡壁破坏过程。这个过程是由于酶失去平衡所致。近二十年来,各国学者对肺气肿的发病学作了大量研究,成功地用蛋 In 1963, Laurell and Eriksson first found that the lack of serum α 1-antitrypsin (α 1 -AT) is closely related to middle-stage emphysema. In 1968, Eriksson proposed a protease-antiprotease balance hypothesis that emphysema formation is a progressive process of alveolar wall destruction. This process is due to an imbalance of enzymes. Nearly two decades, scholars from various countries made a great deal of research on the pathogenesis of emphysema, successfully using eggs