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为了解青霉胺对缺血后再灌注心肌损伤的影响,我们采用Langendrof离体大鼠心脏灌注模型,先灌注15min后停止灌注,模拟缺血60min,然后再灌注60min。动物分为对照组及青霉胺处理组(30mM)。分别测定缺血前及再灌注后心肌组织内三磷酸腺苷(ATP)、谷胱甘肽(GSH)及谷胱甘肽氧化酶(GSH-Px)的含量变化,再灌注过程中冠状动脉血流阻力及冠脉流出液中磷酸肌酸激酶(CPK)的释放量。结果显示,青霉胺处理组再灌注后心肌组织的ATP、GSH、GSH-Px含量均明显高于对照心肌组织中的含量,而青霉胺处理组在再灌注过程中CPK的总释放量及平均冠状血流动脉阻力明显低于对照组CPK总释放量及平均冠状动脉血流阻力。提示青霉胺可以减轻缺血后再灌注的心肌的损伤,起到保护作用
To investigate the effect of penicillamine on myocardial injury induced by ischemia and reperfusion, we used Langendrof isolated rat heart perfusion model. After perfusion for 15 min, perfusion was stopped and the ischemia was simulated for 60 min followed by 60 min reperfusion. Animals were divided into control group and penicillamine treatment group (30mM). The levels of ATP, GSH and GSH-Px in myocardium before and after reperfusion were measured respectively. The changes of coronary flow resistance and Release of phosphokinase (CPK) in coronary effluent. The results showed that the content of ATP, GSH and GSH-Px in myocardium of penicillamine-treated group was significantly higher than that in control myocardium, while the total release of CPK in penicillamine-treated group and Mean coronary blood flow resistance was significantly lower than the control group, the total release of CPK and mean coronary blood flow resistance. Tip penicillamine can reduce myocardial ischemia-reperfusion injury, play a protective effect