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目的:探究不同抗血小板方案治疗急性冠脉综合征的疗效,并分析其预后。方法:选取广州市白云区中医医院收治的急性冠脉综合征患者80例,按照随机数字表法分为对照组(即单抗血小板组)和观察组(即双抗血小板组)各40例,单抗血小板组给予阿司匹林治疗,双抗血小板治疗组给予阿司匹林联合氯吡格雷等治疗,比较两组患者的心脏功能改善水平和预后。结果:治疗前,单抗血小板组和双抗血小板组患者心输出量、心脏射血分数、E/A比值比较差异均无统计学意义(P>0.05),治疗后3月时双抗血小板治疗组各心脏功能指标水平均高于对照组,差异具有统计学意义(P<0.01);随访2年内,双抗血小板组患者不良心脑血管事件发生率(7.5%)明显低于单抗血小板组(22.5%),差异具有统计学意义(P<0.05)。结论:阿司匹林联合氯吡格雷的双抗血小板治疗方案可更好的改善急性冠脉综合征患者的心脏功能水平,利于疾病的恢复和预后。
Objective: To investigate the efficacy of different antiplatelet regimens in the treatment of acute coronary syndromes and analyze their prognosis. Methods: Eighty patients with acute coronary syndrome admitted to Baiyun District Chinese Medicine Hospital of Guangzhou were divided into control group (40) and observation group (40 pairs) respectively according to random number table. Aspirin was given to the platelet-rich group and to aspirin plus clopidogrel in the dual anti-platelet group. The improvement of cardiac function and prognosis were compared between the two groups. Results: Before treatment, there was no significant difference in cardiac output, cardiac ejection fraction and E / A ratio between the patients with monoclonal antibody and antiplatelet group (P> 0.05). The antiplatelet therapy (P <0.01). The incidence of adverse cardiovascular events (7.5%) in patients with dual-antiplatelet group was significantly lower than that in the monoclonal antibody platelet group (22.5%), the difference was statistically significant (P <0.05). Conclusion: The combination of aspirin plus clopidogrel with dual antiplatelet therapy can improve the cardiac function of patients with acute coronary syndrome, which is beneficial to the recovery and prognosis of the disease.