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目的分析糖尿病肾病患者血清脂蛋白、D-二聚体的水平变化及与糖尿病肾病的关系。方法根据尿白蛋白排泄率(Urinary Albumin Excretion rate,UAE)将134例2型糖尿病(Diabetes Mellitus,DM)患者分为单纯糖尿病组(Simple Diabetic Mellitus,SDM组)和糖尿病肾病组(DN组),200例健康体检者作为正常对照组分别测定各组血清Lp(a)、D-D的水平。结果 SDM组Lp(a)和D-D水平与健康对照组比较无统计学差异(P>0.05),但DN组Lp(a)和D-D水平显著高于健康对照组(P<0.01)。结论 DN患者血清Lp(a)和D-D水平明显升高,在DN的早期诊断和病情监测有一定意义。
Objective To analyze the changes of serum lipoprotein and D-dimer in patients with diabetic nephropathy and its relationship with diabetic nephropathy. Methods According to Urinary Albumin Excretion Rate (UAE), 134 patients with type 2 diabetes mellitus (DM) were divided into two groups: Simple Diabetic Mellitus (SDM) and Diabetic Nephropathy (DN) Serum Lp (a) and DD levels were measured in 200 healthy volunteers as normal control group. Results The levels of Lp (a) and D-D in SDM group were not significantly different from those in healthy controls (P> 0.05). However, the levels of Lp (a) and D-D in DN group were significantly higher than those in healthy controls (P <0.01). Conclusion Serum levels of Lp (a) and D-D in patients with DN are significantly higher than those in patients with DN. It is of great significance in the early diagnosis and condition monitoring of DN.