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目的通过分析HPV16-E6蛋白在食管正常组织、不典型性增生组织和癌组织中的表达,探讨HPV16-E6蛋白在梅州地区客家人食管鳞癌组发生、发展中的生物学意义。方法应用免疫组织化学方法检测对68例食管正常黏膜组织、20例上皮不典型增生组织及68例癌组织中HPV16-E6蛋白的表达情况进行研究。结果 HPV16-E6蛋白阳性率在正常食管黏膜组织中为14.7%,在上皮不典型性增生组织中为45.0%,在癌组织中为70.6%,各组间差异有统计学意义(P<0.05)。结论 HPV16-E6蛋白与梅州地区客家人食管鳞癌的发生、发展关系密切。
Objective To investigate the biological significance of HPV16-E6 protein in the occurrence and development of esophageal squamous cell carcinoma in Meizhou area by analyzing the expression of HPV16-E6 protein in esophageal normal tissues, atypical hyperplastic tissues and cancerous tissues. Methods Immunohistochemistry was used to detect the expression of HPV16-E6 protein in 68 cases of esophageal normal mucosa, 20 cases of epithelial dysplasia and 68 cases of carcinoma. Results The positive rate of HPV16-E6 protein was 14.7% in normal esophageal mucosa, 45.0% in epithelial atypical hyperplasia and 70.6% in carcinoma, the difference was statistically significant (P <0.05) . Conclusion The HPV16-E6 protein is closely related to the occurrence and development of esophageal squamous cell carcinoma in Hakka in Meizhou area.