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对50例充血性心力衰竭患者(CHF)及44例健康者进行了血过氧化脂质(LPO)、超氧化物歧化酶(SOD)的检测。结果发现,心力衰竭患者的LPO、血清及红细胞内SOD活力较对照组显著升高;随着心力衰竭加重,LPO、SOD皆增加,SOD/LPO比值下降,LPO含量与心功能呈显著负相关,心力衰竭改善,LPO及SOD减少,SOD/LPO上升。这表明脂质过氧化增强在CHF的发生发展过程中可能起着重要的促进作用,LPO、SOD动态变化可作为判断心力衰竭程度的参考指标。
Blood lipid peroxidation (LPO) and superoxide dismutase (SOD) were measured in 50 CHF patients and 44 healthy controls. The results showed that the activity of SOD in LPO, serum and erythrocytes of heart failure patients was significantly higher than that of the control group. With the increase of heart failure, LPO and SOD increased, the ratio of SOD / LPO decreased, the LPO content had a significant negative correlation with heart function, Heart failure improved, LPO and SOD decreased, SOD / LPO increased. This indicates that increased lipid peroxidation may play an important role in the development and progression of CHF. The dynamic changes of LPO and SOD may be used as a reference index to determine the degree of heart failure.