论文部分内容阅读
目的探究溃疡性结肠炎(ulcerative colitis,UC)与无症状胆结石的关系及其危险因素。方法纳入194例UC患者,按民族、性别、年龄及体质量指数(body mass index,BMI)匹配582名健康体检者作为对照。分析UC患者胆结石的检出率,探讨UC合并胆结石的危险因素。单因素分析采用t检验或χ2检验,多因素分析采用非条件Logistic回归分析。结果 UC患者胆结石检出率为11.86%,健康体检者仅4.64%,差异有统计学意义(P<0.05)。单因素分析显示,民族为维吾尔族、年龄≥50岁、BMI≥24 kg/m2、TG水平升高的UC患者患胆结石的风险显著增加(P<0.05)。多因素分析显示,民族和年龄是UC患者合并胆结石的危险因素(P<0.05)。结论 UC患者可能存在较高的胆结石患病率,民族和年龄是其重要的危险因素,维吾尔族UC患者胆结石的患病率明显高于汉族,随着年龄增长患胆结石的风险增加,UC相关的特异性因素与胆结石的发生无关。
Objective To investigate the relationship between ulcerative colitis (UC) and asymptomatic gallstones and its risk factors. Methods One hundred and ninety-four UC patients were included in the study. 582 healthy subjects were matched by ethnicity, sex, age and body mass index (BMI). To analyze the detection rate of gallstone in UC patients and explore the risk factors of UC complicated with gallstones. Univariate analysis using t test or χ2 test, multivariate analysis using non-conditional Logistic regression analysis. Results The prevalence of gallstones in UC patients was 11.86%, while that in healthy subjects was only 4.64% (P <0.05). Univariate analysis showed that the risk of gallstone was significantly increased in Uighur ethnic UC patients aged ≥50 years with BMI≥24 kg / m2 and elevated TG level (P <0.05). Multivariate analysis showed that ethnicity and age were risk factors for gallstone in UC patients (P <0.05). Conclusion The prevalence of gallstone may exist in UC patients. The ethnicity and age are the important risk factors. The prevalence of gallstones in Uygur UC patients is significantly higher than that in Han people. The risk of gallstone is increased with age, Specificity related to UC has nothing to do with the occurrence of gallstones.