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目的:探讨冠心病(CHD)患者血清超敏C反应蛋白(hs-CRP)水平与冠状动脉病变程度的相关性。方法:对拟诊冠心病的170例患者用免疫散射比浊法进行hs-CRP检测,并行冠状动脉造影(CAG)检查,采用Gensini评分系统对冠状动脉血管病变程度进行定量评分,得出Gensini积分,统计分析冠状动脉狭窄程度与hs-CRP的相关性。结果:由低至高Gensini积分四分位分组后,hs-CRP在不同Gensini积分组间差异有统计学意义(P<0.05)。hs-CRP的水平与Gensini积分呈显著正相关(R=0.382,P<0.01)。结论:血清中hs-CRP浓度的含量与冠状动脉病变的程度呈正相关,可作为临床评价冠状动脉狭窄程度的指标之一。
Objective: To investigate the correlation between the level of serum hs-CRP and the severity of coronary artery disease in patients with coronary heart disease (CHD). Methods: The hs-CRP was detected by immunostaining turbidimetry and coronary angiography (CAG) in 170 patients diagnosed with coronary heart disease. The degree of coronary artery disease was quantitatively scored by Gensini scoring system. Gensini score , Statistical analysis of the degree of coronary stenosis and hs-CRP correlation. Results: From low to high Gensini quartiles, hs-CRP was significantly different among different Gensini scores (P <0.05). The level of hs-CRP was positively correlated with Gensini score (R = 0.382, P <0.01). Conclusion: The serum concentration of hs-CRP is positively correlated with the severity of coronary artery disease, which can be used as one of the indexes for evaluating the severity of coronary artery stenosis.