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目的观察实施宫腔镜手术后应用戊酸雌二醇治疗宫腔粘连的临床效果。方法选取医院实施宫腔镜手术后应用戊酸雌二醇治疗的患者69例为观察组,以同期实施宫腔镜术后未应用戊酸雌二醇治疗的患者69例为对照组,对2组进行定期随访,比较分析治疗效果、子宫内膜厚度、受孕情况及不良反应情况。结果观察组治疗有效率为94.2%,高于对照组的59.4%;观察组患者子宫内膜平均厚度为(9.7±2.7)mm,大于对照组的(4.2±2.3)mm;观察组术后1年成功受孕37例,多于对照组的19例,各项数据组间比较差异均有统计学意义(P<0.05或P<0.01)。观察组69例患者中,有7例服药后有恶心现象,比较轻微,患者可耐受,未见严重肝肾功能异常患者。结论宫腔镜术后应用戊酸雌二醇治疗宫腔粘连效果确切,有助于子宫内膜恢复和受孕,不良反应较少,可进行临床推广。
Objective To observe the clinical effect of estradiol valerate in the treatment of intrauterine adhesions after hysteroscopic surgery. Methods Sixty-nine patients treated with estradiol valerate after hysteroscopic surgery in our hospital were selected as the observation group. Sixty-nine patients who did not receive estradiol valerate after hysteroscopic surgery were selected as the control group, Group regular follow-up, comparative analysis of treatment, endometrial thickness, pregnancy and adverse reactions. Results The effective rate of observation group was 94.2%, which was higher than that of control group (59.4%). The mean endometrial thickness of observation group was (9.7 ± 2.7) mm, which was higher than that of control group (4.2 ± 2.3) mm. 37 cases of successful conception in the year, more than the control group of 19 cases, the data were statistically significant differences between groups (P <0.05 or P <0.01). In the observation group of 69 patients, 7 patients had nausea after taking the medication, and the patient was tolerable. There were no patients with severe liver and kidney dysfunction. Conclusion The application of estradiol valerate after hysteroscopic treatment of uterine cavity adhesion is exact, will help the recovery of endometrium and conception, with fewer adverse reactions, for clinical promotion.