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作者应用细胞色素C还原法,研究了数种平喘药对经FMLP活化的人中性粒细胞(PMN_s)超氧阴离子释放过程的影响。结果显示:异丙肾上腺素、Colforsin和Azelastine对PMN_s释放O_2~-过程具有显著的抑制作用,双丁酰环腺苷酸仅具轻度抑制作用,而AM-682对此过程几无抑制作用。并对上述作用机理和临床意义作了讨论。
The authors used cytochrome C reduction to study the effects of several antiasthmatic agents on the release of superoxide anion from PMN-activated human neutrophils (PMNs). The results showed that isoproterenol, Colforsin and Azelastine had a significant inhibitory effect on PMN_s releasing O_2 ~ - process, while dibutyryl cyclic adenosine monophosphate only had a slight inhibitory effect, while AM-682 had no inhibitory effect on this process. And discussed the mechanism of action and clinical significance discussed above.