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谷胱苷肽S转移酶μ1（glutathioneStransferasesμ1，CSTμ1）对解毒香烟烟雾中的苯并（a）芘等致癌物有重要作用。现已证实正常人中约有50％缺失这种基因，这暗示将增加了肺癌发病的危险性。为了达到早期预防与预测，给新生儿以优育指导。本文采用双重PCR技术对106例新生儿脐血DNA进抒GSTμ1基因检测，并以健康人为对比，研究其缺失率为44．7％，同时新生儿与健康成人不同年龄组、新生儿男、女性别与成人男、女性别缺失率比较，经统计学卡方检验均无显著差异。提示GSTμ1基因缺失是新生儿自身遗传性不良因素，他（她）们如生活在香烟烟雾环境中，发生肿瘤危险性比无GSTμ1缺失的新生儿可能性大。并且通过本研究建立一种快速、准确的基因检测方法，有利于广泛群体筛查，应用临床及科学地指导优育有一定重要意义。
Glutathione S transferase μ1 (CSTμ1) plays an important role in carcinogenesis of benzo (a) pyrene and other carcinogens in detoxified cigarette smoke. It has been confirmed that about 50% of normal people lack this gene, suggesting that it will increase the risk of lung cancer. In order to achieve early prevention and prediction, giving birth to newborn guidance. In this paper, double PCR was used to detect GSTμ1 gene expression in cord blood of 106 newborn infants. Compared with healthy controls, the missing rate was 44.7%. At the same time, newborns and healthy adults of different age groups, Do not and adults, male and female loss rate comparison, the statistical chi-square test showed no significant difference. It is suggested that the loss of GSTμ1 gene is a hereditary adverse factor in neonates. He / she is more likely to have a tumor risk than a non-GSTμ1-deleted newborn if they live in a cigarette smoke environment. And through this study to establish a rapid and accurate method of genetic testing, is conducive to screening a wide range of groups, the clinical and scientific guidance of the application of fertility has some significance.