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目的 :探讨丹参、地塞米松、L -精氨酸、维拉帕米在肝脏缺血预处理 (IPC)过程中的作用 ;方法 :在原位灌流的大鼠肝脏缺血再灌注模型上 ,经尾静脉注射丹参、地塞米松、L -精氨酸和维拉帕米 ,检测上述药物在IPC中的疗效 ;结果 :药物预处理组与对照组比较 ,药物预处理可阻止血清谷丙转氨酶 (ALT ,U/L) 1 3 7.7± 1 5.6、1 4 2 .6± 1 5.9、1 4 6.3±1 3 .7、1 4 2 .8± 1 5.7与 1 74.7± 2 3 .9;谷草转氨酶 ( (AST ,U/L) 2 63 .1± 2 3 .5、2 56.8± 2 8.7、2 72 .5± 2 2 .5、3 2 9.3± 3 6.5与 3 40 .2± 3 8.3 ;乳酸脱氢酶 (LDH ,U/L) 1 2 0 6± 1 3 7、1 2 96±1 1 8、1 2 2 0± 1 2 7、1 2 76± 1 2 3与 2 568± 1 53及脂质过氧化物 (MDA ,mmol/L) 2 9.7± 5.4、2 7.6± 4.5、2 7.8± 4.7、2 7.6± 5.7与 3 8.7± 7.6水平升高 (P <0 .0 1 ) ;而使超氧化歧化酶(SOD ,mu/L) 95.1± 1 0 .2、92 .4± 1 1 .4、92 .4± 1 0 .5、95.3± 1 0 .8与 73 .7± 5.4;一氧化氮(NO ,mmol/L) 81 .5± 7.9、86.4± 9.4、88.3± 9.6、76.3± 8.6与 64.2± 6.8保持在较高水平 (P <0 .0 1 ) ;药物预处理组肝脏病理改变程度明显轻于缺血再灌注组 ,但维拉帕米不如丹参、地塞米松、L -精氨酸的疗效 (P <0 .0 5) ;结论 :药物预
Objective: To explore the role of Salvia miltiorrhiza, dexamethasone, L - arginine and verapamil in hepatic ischemic preconditioning (IPC). Methods: In the rat model of hepatic ischemia - reperfusion induced by in situ perfusion, Salviae miltiorrhizae, dexamethasone, L-arginine and verapamil were injected through the tail vein to detect the efficacy of the above drugs in IPC. Results: Compared with the control group, drug pretreatment could prevent the serum alanine aminotransferase (ALT, U / L) 1 3 7.7 ± 1 5.6,1 4 2 .6 ± 1 5.9,1 4 6.3 ± 1 3 .7,1 4 2 .8 ± 1 5.7 vs 1 74.7 ± 23.9; Aminotransferase (AST, U / L) 2 63 .1 ± 2 3 .5 2 56.8 ± 2 8.7 2 72 .5 ± 2 2 .5 3 2 9.3 ± 3 6.5 vs 3 40 .2 ± 3 8.3; Lactate dehydrogenase (LDH, U / L) 1 2 0 6 ± 1 3 7,1 2 96 ± 1 1 8,1 2 2 0 ± 1 2 7,1 2 76 ± 1 2 3 and 2 568 ± 1 53 And lipid peroxidation (MDA, mmol / L) 2 9.7 ± 5.4,2 7.6 ± 4.5,2 7.8 ± 4.7,2 7.6 ± 5.7 and 3 8.7 ± 7.6 levels (P <0.01); and The superoxide dismutase (SOD, mu / L) 95.1 ± 10.2, 92.4 ± 1 1 .4, 92.4 ± 105.0, 95.3 ± 1.08 and 73.7 ± 5.4; Nitric oxide (NO, mmol / L) 81.5 ± 7.9,86.4 ± 9.4, 88.3 ± 9.6, 76.3 ± 8.6 and 64.2 ± 6.8, respectively (P <0.01). The degree of liver pathological changes in drug pretreatment group was significantly lower than that in ischemia / reperfusion group, but verapamil Not as good as salvia miltiorrhiza, dexamethasone, L - arginine efficacy (P <0 05); Conclusion: drug pre