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目的：观察血液透析对慢性肾功能衰竭患者血浆纤维蛋白原的影响。方法：纤维蛋白原用计算机自动检测系统测定，Ｄ－二聚体用ＥＬＩＳＡ法，ＦＤＰ用纸片凝集法。结果：２０例慢性肾功能衰竭患者透析前、后各项参数为：ＦＭＰＶ：０．５６９±０．１３０，０．６８０±０．１５０；Ａｍａｘ：０．２８１ ±０．０５５，０．３４５±０．０６５；Ｓ（ｇ／Ｌ）：３．１５±０．７０．３．９８±０．８５；ＤＴ（ｓｅｃ）：１５±３，２０±４，ＦＭＰＶ／Ａｍａｘ：２．０２４，１．９７１：Ｄ──二聚体（ｍｇ／Ｌ）：０．９０５，０．９９５；ＦＤＰ（ｍｇ／Ｌ）：６．０６，６．７６。结论：慢性肾功能衰竭患者血浆纤维蛋白原水平、功能及纤溶活力均高于正常对照组，血液透析后各项指标没有改善，甚至仍有上调。
Objective: To observe the effect of hemodialysis on plasma fibrinogen in patients with chronic renal failure. Methods: Fibrinogen was detected by computer automatic detection system, D-dimer by ELISA method, FDP by paper agglutination method. Results: The parameters before and after dialysis in 20 patients with chronic renal failure were as follows: FMPV: 0.569 ± 0.130,0.680 ± 0.150; Amax: 0.281 ± 0.055,0.345 ± 0.065; S (g / L): 3.15 ± 0.70.3.98 ± 0.85; DT (sec): 15 ± 3,20 ± 4, FMPV / Amax: 2.024,1. 971: D ─ ─ dimer (mg / L): 0.905,0.995; FDP (mg / L): 6.06,6.76. Conclusion: The levels of plasma fibrinogen, function and fibrinolytic activity in patients with chronic renal failure are higher than those in normal control group, and the indicators of hemodialysis are not improved or even increased.