系统性红斑狼疮(SLE)是一种较常见的系统性自身免疫病,自然转归差,发病机制与遗传和环境因素有关。Epstein-Barr病毒(EBV)感染与SLE发病的相关性长久以来受到学者们的关注。近年在血清学、病毒基因组学、实验动物及流行病学等方面,均有研究证明EBV可能通过分子模拟机制导致易感群体发病。文章就EBV感染与SLE发病相关机制的研究进展进行综述。 Systemic lupus erythematosus (SLE) is a more common systemic autoimmune disease that naturally has poor outcomes and its pathogenesis has been linked to genetic and environmental factors. Epstein-Barr virus (EBV) infection and the incidence of SLE has long been the concern of scholars. In recent years, in serology, viral genomics, laboratory animals and epidemiology, studies have shown that EBV may lead to the pathogenesis of susceptible groups through molecular modeling. The article reviews the progress of research on the mechanisms of EBV infection and SLE.