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作者采用放血的方式诱导休克,并在30分钟后给予“新红细胞”(NRC),采用实验手段检测血液动力学氧运输量指标观察NRC对严重休克作用。7只小猎犬用于本项试验。静脉麻醉术后,作气管内插管,并吸入50％的氧。抽取动物静脉血的速率为30ml/分钟。动物的休克定义为心脏收缩血压60～69mmHg。30分钟后,给予NRC,并重复。NRC的用量为放血体积的1.5倍以使动物从休克状态中恢复。动物可耐受休克3次,但不能从4次休克中恢复过来。NRC增加了全血大约1/3的粘度,使用后血管内阻力增加而心输出量降低,导致心脏衰竭。另外,由于休克导致氧消耗增加。NRC通过升高AV差的方式弥补心输出量减少,满足氧需求。但
The authors induced the shock by means of exsanguination and given “new red blood cells” (NRC) after 30 minutes. The hemodynamic oxygen transport index was measured by experimental means to observe the effect of NRC on severe shock. Seven beagle dogs were used in this experiment. After intravenous anesthesia, endotracheal intubation and inhalation of 50% oxygen. Animal venous blood was withdrawn at a rate of 30 ml / minute. Animal shock is defined as systolic blood pressure 60 ~ 69mmHg. After 30 minutes, give NRC and repeat. The amount of NRC used was 1.5 times the volume of the bleeding to restore the animal from the shock state. Animals can tolerate shock three times but can not recover from four shocks. NRC increases the viscosity of whole blood by about 1/3, increases the intravascular resistance after use and decreases cardiac output, leading to heart failure. In addition, oxygen consumption increases due to shock. The NRC compensates for the decrease in cardiac output by raising the AV difference to meet oxygen demand. but