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丙型肝炎病毒(hepatitis C virus,HCV)除感染肝脏外,还可以侵犯淋巴系统、肾脏、骨髓、甲状腺等多个组织和器官。因此,慢性丙型肝炎(chronic hepatitis C,CHC)患者在临床除了出现肝脏受损的表现外,还可以出现多器官受累的临床表现,如合并糖尿病、肾病、自身免疫性疾病、血液系统疾病等,使CHC的治疗变得比较复杂,特别是使用干扰素进行抗病毒治疗时,既要考虑药物的有效性,又要避免对其他伴随疾病的影响。本期笔谈结合最近的临床研究,对CHC患者合并上述其他内科疾病的临床特点、疾病间的相互影响以及治疗策略进行专题讨论,其目的是为了指导临床医生更好地认识和治疗CHC合并其他疾病的患者。
In addition to liver infection, hepatitis C virus (HCV) can invade multiple tissues and organs such as the lymphatic system, kidney, bone marrow and thyroid. Therefore, in addition to clinical manifestations of liver damage, patients with chronic hepatitis C (CHC) may also have clinical manifestations of multiple organ involvement such as diabetes, nephropathy, autoimmune diseases, hematological diseases, etc. , Make the treatment of CHC more complicated, especially when using interferon for antiviral therapy, it is necessary to consider the effectiveness of the drug, but also to avoid the impact of other concomitant diseases. In this review, we combine recent clinical studies to conduct a thematic discussion on the clinical features of CHC patients with other medical conditions, the interplay between diseases, and treatment strategies to guide clinicians to better understand and treat CHC with other diseases Of patients.