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目的:探讨别嘌醇引起皮肤系统不良反应的表现及发生规律,为临床安全用药提供参考。方法:我院不良反应监测系统2005年1月～2012年3月使用别嘌醇引起的皮肤系统不良反应病例进行统计分析。结果:共检索到ADR 64例,以中老年居多(51例,79.7%),其常用日剂量为50～100 mg(51例,79.7%),潜伏期2 d～4个月不等;皮肤系统ADR的临床表现以一般型、剥脱性皮炎型及多形红斑型的药疹为主,占73.4%,60%患者有伴随症状。结论:临床应重视别嘌醇皮肤系统不良反应的危害性。对老年患者更应注意密切观察用药后反应,确保用药安全。
Objective: To investigate the manifestations and occurrence of adverse reactions of allopurinol caused by the skin system, and to provide reference for the clinical use of drugs. Methods: Adverse reaction monitoring system in our hospital from January 2005 to March 2012 using allopurinol induced adverse reactions of the skin system for statistical analysis. Results: A total of 64 cases of ADR were found in the middle-aged and elderly population (51 cases, 79.7%). The common daily dose was 50-100 mg (51 cases, 79.7%) and the incubation period was 2-4 days. Clinical manifestations of ADR with general type, exfoliative dermatitis and erythema multiforme type drug eruption mainly accounted for 73.4%, 60% of patients with concomitant symptoms. Conclusion: Clinical should pay attention to all the hazards of adverse reactions of allopurinol skin system. More attention should be paid to elderly patients should observe the reaction after medication to ensure drug safety.