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目的:动态观察脑出血(CH)及蛛网膜下腔出血(SAH)患者血浆神经肽Y(NPY)的水平变化,探讨NPY与出血性脑血管病发生、发展的关系。方法:采用放射免疫法测定了46例脑出血,30例SAH患者及28例健康人血浆NPY的含量。结果:CH和SAH患者血浆NPY水平均明显高于对照组(P<0.001)。发病24小时内即显著升高,4～7天达高峰,8～15天开始下降,15天后CH组仍维持较高水平。重型CH患者NPY水平显著高于轻型和中型。大面积出血组高于小面积出血组。SAH患者伴迟发性缺血性障碍(DID)组明显高于不伴DID组。结论:NPY可能在CH及SAH的发生及病理生理过程中起重要作用。
Objective: To observe the changes of plasma neuropeptide Y (NPY) levels in patients with cerebral hemorrhage (CH) and subarachnoid hemorrhage (SAH) and explore the relationship between NPY and the occurrence and development of hemorrhagic cerebrovascular disease. Methods: Radioimmunoassay was used to determine the plasma levels of NPY in 46 patients with cerebral hemorrhage, 30 patients with SAH and 28 healthy controls. Results: Plasma NPY levels in patients with CH and SAH were significantly higher than those in the control group (P <0.001). Within 24 hours of onset was significantly increased, reaching a peak 4 to 7 days, 8 to 15 days began to decline, CH group remained high after 15 days. NPY levels in patients with severe CH were significantly higher than those in mild and moderate. Large area bleeding group than small area bleeding group. SAH patients with delayed ischemic disorder (DID) was significantly higher than the group without DID. Conclusion: NPY may play an important role in the pathogenesis of CH and SAH and pathophysiology.