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1955年Sneath等证明Lewis血型系统主要是由血清和体液中的可溶性抗原组成,致敏于红细胞而形成 Le 血型,这是一种体液抗原。大多数 Le~(a-b-)型的人容易受 Le~a 和 Le~b 抗原刺激产生抗 Le~a和 Le~b 抗体,而 Le 抗体与补体结合,可引起溶血反应.最近我们遇到一例再生障碍性贫血患者,因反复输血,产生抗 Le~a、抗 Le~b、抗 P 以及抗粒细胞抗体,以致引起轻度溶血及发热反应.患者戴××,女性,38岁,诊断为再生障碍性贫血.患者自觉乏力,伴低热头昏,月经过多,齿龈等容易出血,因血红蛋白仅5～6克%左右,日常
In 1955, Sneath et al. Demonstrated that the Lewis blood group system is mainly composed of soluble antigens in serum and body fluids and sensitizes erythrocytes to form Le blood type, which is a humoral antigen. Most Le ~ (ab-) type of people susceptible to Le ~ a and Le ~ b antigen stimulation Le ~ a and Le ~ b antibodies, and Le antibody and complement, can cause hemolysis. Recently, we encountered a case Patients with aplastic anemia, due to repeated transfusions, resulting in anti-Le ~, anti-Le ~ b, anti-P and anti-granulocyte antibodies, resulting in mild hemolysis and fever response.Day × ×, female, 38 years old, diagnosed as Aplastic anemia patients with fatigue, with fever dizziness, menorrhagia, gums and other easy to bleeding, hemoglobin only about 5 to 6 grams%, daily