论文部分内容阅读
Background:Body mass index(BMI)has a U?shaped association with lung cancer risk.However,the effect of BMI on prognosis is controversial.This retrospective study aimed to investigate the effect of BMI on the survival of patients with stage I non?small cell lung cancer(NSCLC)after surgical resection.Methods:In total,624 consecutive stage I NSCLC patients who underwent radical resection were classified into four groups according to their BMI:underweight(BMI<18.5 kg/m~2),normal weight(BMI obese(BMI>28.0 kg/m~2).The effect of BMI on progress=18.5–22.4 kg/m2),overweight(BMI=22.5–28.0 kg/m~2),andion?free survival(PFS)and over?all survival(OS)was estimated using the Kaplan–Meier method and Cox proportional hazards model.Postoperative complications in each group were analyzed using the Chi square test or Fisher’s exact test.Results:A univariate analysis showed that PFS and OS were longer in the overweight group than in other groups(both P<0.05).A multivariate analysis showed that OS was longer in the overweight group than in other groups(compared with the other three groups in combination:hazard ratio[HR]e underweight group:HR=1.87,95%confidence interval[CI]1.30–2.68,P=0.003;compared with th3,P=2.24,95%CI 1.18–4.25,P=0.013;compared with the normal weight group:HR 1.48–5.59,P=1.58,95%CI 1.07–2.3=0.022;compared with the obese group:HR=2.87,95%CIwe=0.002),but PFS was similar among the groups(HRd an association between being overweight and pro=1.28,95%CI 0.97–1.68,P longed OS in patients at sta=0.080).A subgroup analysis shoge T1a(P 0.001).Overweight=0.024),T1b(P=0.051),and T2a(P=0.02),as well as in patients with a non?smoking history(P=patients had lower rates of postoperative complications,such as respiratory failure(compared with the underweight and obese groups:P=0.014),myocardial infarction(compared with the obese group:P=0.033),and perioperative death(com?pared with the other three groups:P=0.016).Conclusions:Preoperative BMI is an independent prognostic factor for stage I NSCLC patients after resection,with overweight patients having a favorable prognosis.
Background: Body mass index (BMI) has a U? Shaped association with lung cancer risk. However, the effect of BMI on prognosis is controversial. This retrospective study aimed to investigate the effect of BMI on the survival of patients with stage I non? Small cell lung cancer (NSCLC) after surgical resection. Methods: In total, 624 consecutive stage I NSCLC patients who underwent radical resection were classified into four groups according to their BMI: underweight (BMI <18.5 kg / (BMI obese BMI> 28.0 kg / m 2). The effect of BMI on progress = 18.5-22.4 kg / m 2, and overweight BMI = 22.5-28.0 kg / m 2. and over? all survival (OS) was estimated using the Kaplan-Meier method and Cox proportional hazards model. Postoperative complications in each group were analyzed using the Chi square test or Fisher’s exact test. Results: A univariate analysis showed that PFS and OS were longer in the overweight group than in other groups (both P <0.05). A multivariate analysis showed that OS was longer in the overweight group than in other groups (compared with the other three groups in combination: hazard ratio [HR] e underweight group: HR = 1.87, 95% confidence interval [CI] 1.30-2.68, P = 0.003; P = 2.24, 95% CI 1.18-4.25, P = 0.013; compared with the normal weight group: HR 1.48-5.59, P = 1.58, 95% CI 1.07-2.3 = 0.022; compared with the obese group: HR = 2.87 , 95% CIwe = 0.002), PFS was similar among the groups (HRd an association between being overweight and pro = 1.28, 95% CI 0.97-1.68, P longed OS in patients at sta = 0.080). A subgroup analysis shoge T1a (P 0.001). Overweight = 0.024), T1b (P = 0.051), and T2a (P = 0.02), as well as in patients with a non smoking history (P = patients had lower rates of postoperative complications, such as respiratory (compared with the underweight and obese groups: P = 0.014), myocardial infarction (compared with the obese group: P = 0.033), and perioperative death (com pared with the other three groups: P = 0.016) .Conclusions: Preoperative BMI is an independent prognostic factor for stage INSCLC patients after resection, with overweight patients having a favorable prognosis.