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目的:通过系统性文献检索和meta分析评估调节性T细胞与肝癌患者生存时间的相关性。创新点:针对调节性T细胞在肝癌患者中的预后意义进行系统性文献综述和分析,进一步证实其可以作为预测肝癌预后的指标。方法:在MEDLINE和Embase数据库中搜索相关文献,提取数据并对文献质量进行评估。有18项研究纳入到最后的分析,包括的肝癌患者多数为乙肝病毒感染。利用meta分析的方法对相关结果进行合并分析。结论:本实验证实,肿瘤组织内调节性T细胞与肝癌患者预后显著相关,调节性T细胞数量高的患者生存时间和无瘤生存期均较短。同样,外周循环调节性T细胞数量与肝癌患者生存期也呈负相关。
OBJECTIVE: To evaluate the relationship between regulatory T cells and survival in patients with liver cancer through systematic literature search and meta-analysis. Innovative point: regulatory T cells in patients with liver cancer prognostic significance of systematic literature review and analysis, and further confirmed that it can be used as an indicator of prognosis of liver cancer. METHODS: MEDLINE and Embase databases were searched for relevant literature, data were extracted and quality of literature evaluated. There are 18 studies included in the final analysis, including the majority of liver cancer patients with hepatitis B virus infection. Meta-analysis of the results of the merger analysis. CONCLUSIONS: This experiment confirms that Tregs in tumor tissues are significantly associated with the prognosis of HCC patients. Patients with high numbers of Tregs have shorter survival and tumor-free survival. Similarly, the number of circulating regulatory T cells and liver cancer patients with a negative correlation between the survival.