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龙心胶囊具有益气活血、化瘀通络的功效,主治脑血栓、脑梗塞等病症,本研究观察该药对大鼠局灶性脑缺血的影响,探讨其疗效机制。材料与方法1 材料1.1 药物龙心胶囊系由黄芪、地龙、丹参等中药组成。本实验用其提取干粉,每克干粉含生药5.0g,山东济宁华能生科医药保健品厂提供;尼莫地平,每片20mg,天津市中央制药厂生产(批号960418);硫代巴比妥酸,Sigma 公司出品;黄嘌呤氧化酶,Fluka 公司出品;鲁米诺。Boehringer Marmheim 公司出品。1.2 动物 SD 大鼠,50只,雄性,体重250～
Longxin Capsule has the effects of replenishing qi and activating blood circulation and removing blood stasis and collaterals. It treats cerebral thrombosis, cerebral infarction and other diseases. This study was to observe the effect of this medicine on focal cerebral ischemia in rats and to explore its therapeutic mechanism. Materials and Methods 1 Materials 1.1 Drugs Longxin capsules are composed of Chinese herbs such as Radix Astragali, Radix Dioscorea, and Radix Salviae Miltiorrhizae. This experiment used its extracted dry powder, containing 5.0g crude drug per gram dry powder, provided by Shandong Jining Huanengshengke Medicine and Health Products Factory; Nimodipine, 20mg per tablet, produced by Tianjin Central Pharmaceutical Factory (lot 960418); Thiobarbital Acid, produced by Sigma; xanthine oxidase, produced by Fluka; luminol. Produced by Boehringer Marmheim. 1.2 Animal SD rats, 50 males, weighing 250～