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肺癌是肿瘤致死的主要原因,其发病率与死亡率均位于疾病谱的前列。引起肺癌发生的最主要危险因素是吸烟,同时,还发现其他一些环境危险因素,包括放射性物质、石棉、金属和营养因素。肺癌中异常的DNA甲基化效应阐明了环境因素和肿瘤抑制关键基因相互作用的机制及其影响肺癌的方式。随着对肺癌发生机制的不断深入研究,环境因素诱发的DNA异常甲基化有望成为肺癌有潜力优势的诊断或预后标记物。某些特异基因的甲基化和肺癌密切相关,是肺癌发生常见的早期事件,这对于肺癌的早期诊断有十分重要的意义。
Lung cancer is the leading cause of cancer death and its morbidity and mortality are at the forefront of disease spectrum. The most significant risk factor for lung cancer is smoking, along with other environmental risk factors including radioactive materials, asbestos, metals and nutrients. Aberrant DNA methylation in lung cancer elucidates the mechanisms by which environmental factors and tumor suppress key genes interact and how they affect lung cancer. With the continuous research on the mechanism of lung cancer, DNA abnormal methylation induced by environmental factors is expected to become a potential diagnostic or prognostic marker for lung cancer. The methylation of some specific genes is closely related to lung cancer, which is a common early event in lung cancer. This is very important for the early diagnosis of lung cancer.