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已有报道西咪替丁、雷尼替丁、苯妥因、静脉脂肪乳和肝素可能引起血小板减少症。头孢菌素虽有报道能引起血小板减少症,但较罕见。去年作者所在监护病室有两例血小板减少症可能与使用头孢他啶(ceftazidime)有关,但当时病人也接受了肝素治疗,因此未能证明因果关系,而作者认为这两个病例因头孢三嗪和头孢他啶伍用引起了血小板减少症。一名82岁女性,因肺炎和晕厥发作住院治疗,无胃肠出血和其它可致血小板减少的情况。5月24～28日患者静滴头孢呋新750mg,q8h,后因皮疹而停药,此间血小板在正常范围内。6月4日给青霉素3000000U,发现过敏即停用。6月5日和6日用头孢他啶1givq8h,6月7～9日用头孢三嗪1givq24h。6月6日发现病人的血小板数在下
It has been reported that cimetidine, ranitidine, phenytoin, intravenous fat emulsion and heparin may cause thrombocytopenia. Although there are reports of cephalosporins can cause thrombocytopenia, but rare. Last year, two cases of thrombocytopenia at the author’s ICU were associated with the use of ceftazidime, but at the time, patients were also treated with heparin and therefore failed to prove a causal relationship. The authors concluded that the two cases were due to ceftriaxone and ceftazidime Used to cause thrombocytopenia. An 82-year-old woman hospitalized for pneumonia and syncope without gastrointestinal bleeding and other thrombocytopenia. May 24 to 28 patients with intravenous cefuroxime 750mg, q8h, after the withdrawal due to a rash, during which platelets within the normal range. June 4 to penicillin 3000000U, found to be disabled allergy. Ceftazidime 1givq8h on June 5 and 6, ceftriaxone 1givq24h on June 7-9. June 6 found that the patient’s platelet count in the next